If you're chemically sensitive, it's probably not a good idea to get it installed, but it's also not a good idea to breathe musty air from the crawl space either. In addition, your house and its contents are made of lots of materials that affect your indoor air quality. If you're really concerned about this, hire a company to test your air and tell you what you can do about it.
I have used the Froth-Pak 200 to air-seal rim joists--the area above the foundation wall in a basement. The first time I used it I did not shake the canisters well enough and the foam did not cure properly. Don't just shake the box for a few seconds. I take the tanks out of the box so I can shake/invert each tank for a minute or two. You will be able to hear the chemical sloshing around in the tanks. Also, don't ignore the recommended temperature for application--around 75 degrees F. https://youtube.com/watch?v=ggLAUsiuI_o&app=desktop
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Light-density open-cell SPF is commonly known as half-pound foam. It is a semi-rigid material with a sponge-like appearance that expands during installation and creates small, open cells that are filled with carbon dioxide. Due to its ability to expand during the application process, it fills cracks, crevices and voids and adheres to irregular surfaces or substrates to form an air sealing insulation.