Sporadic cases of hypersensitivity pneumonitis (HP) have also been reported in workers exposed to isocyanates. The symptoms may seem like the flu, with fever, muscle aches, and headaches. Other symptoms may include a dry cough, chest tightness, and difficult breathing. Individuals with chronic HP often experience progressively more difficult breathing, fatigue, and weight loss. Individuals with acute HP typically develop symptoms 4–6 hours after exposure.[4]
Global warming potential (GWP), as defined by the EPA, is a measure of how much energy the emissions of 1 ton of a gas will absorb over a given period of time, relative to the emissions of 1 ton of carbon dioxide (CO2).  Spray foam insulation products that use water as the blowing agent - typically open-cell foam however Icynene’s ProSeal Eco is a 100 percent water blown closed-cell spray foam – have a global warming potential of 1, the lowest possible number.  This is because water in the mixture reacts during the application process to release carbon dioxide and heat. The GWP of the blowing agent is that of carbon dioxide. Carbon dioxide has a GWP of 1.
If you're chemically sensitive, it's probably not a good idea to get it installed, but it's also not a good idea to breathe musty air from the crawl space either. In addition, your house and its contents are made of lots of materials that affect your indoor air quality. If you're really concerned about this, hire a company to test your air and tell you what you can do about it. https://www.youtube.com/v/ggLAUsiuI_o?version=3

Spray foam’s thermal performance and advanced air and moisture control can be optimized by combining it with other insulation products like fiberglass batts or rolls, maximizing budget and meeting energy efficiency goals. Combining insulation products creates a custom solution by leveraging the functions of multiple materials to find the best mix for the project. 
Acrylic coatings are typically applied in two coats, with the second running perpendicular to the first. 1 gallon per 100 square feet is a good estimate for these coatings, as they do not need to be applied nearly as thick as many other coatings. These coatings can be sprayed or roll-applied. Acrylic coatings generally require a re-coat within 2-3 years of application.

Spray Foam Roof Insulation

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